PT-141

Description

PT-141, also known as bremelanotide, is a synthetic cyclic peptide research material derived from the melanocortin peptide family. Its structure incorporates an N-terminal acetyl group, norleucine, D-phenylalanine, and an intramolecular cyclic linkage that creates a conformationally constrained peptide architecture. It is produced through controlled peptide synthesis and used in laboratory settings for analytical, biochemical, receptor-binding, and molecular investigations under defined experimental conditions. The material is commonly supplied in lyophilized form to support stability and integrity during appropriate laboratory storage and handling.

Research Applications:

PT-141 may be utilized in controlled laboratory research settings for applications such as:

• Analytical characterization of cyclic peptide identity, structure, and physicochemical properties
• Investigation of peptide-receptor interactions in controlled biochemical and cell-based assay systems
• Evaluation of peptide stability and degradation behavior under defined experimental conditions
• Examination of structure-activity relationships involving cyclic melanocortin-related peptide architectures

Storage and Handling:

• Store lyophilized material at -20°C or according to batch-specific supplier documentation.
• Protect the material from excessive moisture, heat, and prolonged light exposure.
• Once prepared in solution, follow validated stability data and the specific laboratory protocol for storage conditions.
• Avoid unnecessary repeated freeze-thaw cycles and use appropriate laboratory handling procedures to minimize contamination and degradation.

Product Specifications:

• Purity: Refer to batch-specific HPLC results or Certificate of Analysis
• Appearance: Typically supplied as a white to off-white lyophilized powder; verify against batch-specific documentation
• Solubility: Dependent on concentration, pH, salt form, formulation, and solvent system; refer to supplier-specific technical documentation

Compliance Notice:

PT-141 is FOR RESEARCH USE ONLY. It is not intended for human or veterinary use. This product is supplied exclusively for controlled laboratory, analytical, and in vitro research purposes and is not intended for diagnostic, therapeutic, or clinical applications. Misuse of this product is strictly prohibited and may violate applicable federal, state, or local laws. By purchasing this product, the buyer represents and warrants that it will be used solely for legitimate laboratory research purposes.

Technical Note: The molecular formula C₅₀H₆₈N₁₄O₁₀ and molecular weight of approximately 1025.18 g/mol correspond to the commonly referenced free molecular form of PT-141 (bremelanotide). The peptide is structurally represented as Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH, with cyclization formed through an intramolecular lactam linkage. Commercial research materials may be supplied as acetate or other salt forms, which can alter the reported molecular weight and analytical specifications. Final product-page information should therefore match the supplier documentation and batch-specific Certificate of Analysis (COA).